complement
Immune Defense Cascade
Plain-language definition
A system of blood proteins enhancing the immune response. Overactivation contributes to tissue damage in NMO and geographic atrophy (advanced dry AMD).
Where this term comes up
“Eculizumab (Soliris) is a monoclonal antibody that blocks complement protein C5, part of the immune system.”
Medication · Eculizumab (Soliris)
“MRI is usually better for optic nerve and soft tissue - CT and MRI complement each other”
Test · CT Scan (Head/Orbits)
“Pegcetacoplan and avacincaptad pegol are intravitreal complement inhibitors, first FDA-approved in 2023”
Condition · Geographic Atrophy
- Category
- Immune system term
- Also written as
- No alternate forms listed.
Immunology terms describe immune-system activity, antibodies, inflammation, or autoimmune processes that can affect the eyes and nerves.
Related glossary terms
A note on medical context
A glossary definition can explain a word, but it cannot tell you whether a symptom or test result is serious. If this term came from an article, use the full article and your clinician's guidance for context.